Jake Gyllenhaal Searcher Clade (voice) Dennis Quaid Jaeger Clade (voice) Jaboukie Young-White Ethan Clade (voice) Gabrielle Union Meridian Clade (voice) Lucy Liu Callisto Mal (voice) Alan Tudyk Narrator / Radio Host 1 / Duffle (voice) Jonathan Melo Diazo (voice) Abraham Benrubi Lonnie Redshirt (voice) Karan Soni Caspian (voice) Adelina Anthony Pulk (voice) Nik Dodani Kardez (voice) Francesca Reale Azimuth (voice) Emily Kuroda Ro (voice) Reed Buck Rory (voice) Katie Lowes Radio Host 2 (voice)